Endocrine Abstracts

Chronotype is defined as a trait determining the subject circadian preference in behavioral and biological rhythms relative to external light-dark cycle.The morning chronotype (MC) prefers activities earlier in the day, while the evening chronotype (EC) perform its main activity late in the day. Intermediate chronotype (IC) is in an intermediate position between MC and EC. EC as well as menopause have been associated to an increased risk of cardiometabolic diseases (CMD) in ob...

Background: Polycystic Ovary syndrome (PCOS) is the most common endocrine disorders in women of reproductive age whose lifestyle approach is an essential part of the treatment. Recently chronotype, i.e. a trait that determines individual’s circadian preference in behavioral and biological rhythms, has been reported to play a role in determining nutrition preferences and the risk of developing chronic diseases. Thus, the aim of the study was to investigate if chronotype ca...

Very Low-Calorie Ketogenic Diet (VLCKD) is currently a promising approach for the treatment of obesity. However, little is known about the side effects since most of the studies reporting them were carried out in normal weight subjects following ketogenic diet for other purposes than obesity. Thus, the aims of the study were: 1) to investigate the safety of VLCKD in subjects with obesity; 2) if VLCKD-related side effects could have an impact on its efficacy. In this prospectiv...

Background: Obesity can damage kidney via directly, through the production of pro-inflammatory adipocytokines, and indirectly due to systemic complications. Several strategies are available for weight loss (lifestyle, anti-obesity drugs and surgery therapy), but there are no guidelines to manage subjects with obesity and chronic kidney disease. Very low-calorie ketogenic diet (VLCKD) is an increasingly used tool for weight loss in subjects with obesity. Thus, we aimed to inves...

Introduction: Currently, patients with type 1 diabetes (T1D) have the option of being treated with Hybrid Closed Loop (AHCL) systems, which allow insulin delivery to be modulated according to glycemic values. These systems do not allow any kind of anthropometric or laboratory characteristics to be used to enhance the devices’ capabilities. Thus, the aim of our study was to investigate the efficacy of AHCL systems in subjects with T1D and with obesity compared to normal-we...

Introduction: A higher adherence (HA) to the Mediterranean Diet (MD) is associated to a lower risk of developing type 2 diabetes (T2DM). However it is less clear if this is caused by a “food cluster” (FC) or a single MD food effect on the insulin-resistance (IR) and/or on the insulin-secretion (IS).Aim: This study investigated the association between MD adherence, IR and IS, indirectly measured, in subjects affected by obesity without diabetes ...

Introduction: The VLCKD is an established diet regimen with positive metabolic effects. Based on that, it was hypothesized that VLCKD could also have positive effects on glucose metabolism and insulin resistance, as well as obesity. Specifically, we aimed to investigate the efficacy of VLCKD on glucose metabolism in subjects with obesity compared to Mediterranean Diet.Methods: In this cross-sectional study anthropometric parameters (weight, height and wa...

Objective: Polycystic ovary syndrome (PCOS) is the most common female endocrine disorder. Recently in the context of obesity, which often coexists with PCOS, it has been highlighted the role of chronotype as risk factor for obesity-related cardiometabolic complications. Given the importance of chronotype categories in the context of metabolic diseases and being PCOS characterized by metabolic derangements, we aimed to investigate the prevalence of chronotype categories in wome...

Metabolic syndrome and obesity (MetS) are supposed to have a role in cancer but data analysing their association with GEP-NET are lacking. Aim of this study was to explore the association of early predictors of MetS with GEP-NET, usingas tools Fatty Liver Index (FLI), a predictor of non-alcoholic fatty liver disease (NAFLD)and Visceral Adiposity Index (VAI), a gender-specific indicator of adipose dysfunction. A cross-sectional case-control observational study was conducted. VA...

Insulin resistance (IR), characterized by an impairment of target tissues to insulin responsiveness, is the core defect preceding diabetes. Preclinical and clinical data have suggested a role for the dopaminergic system in glucose homeostasis control. The aim of the current study was to investigate the role of the dopamine agonist cabergoline (CAB), displaying high affinity for dopamine type 2 (DR2) receptor and low affinity for serotonin receptors (5-HTRs), in the regulation ...